The Chemokine SDF1/CXCL12: A Novel Autocrine/Paracrine Factor Involved In Pituitary Adenoma Development
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چکیده
منابع مشابه
The Chemokine SDF1/CXCL12: A Novel Autocrine/Paracrine Factor Involved In Pituitary Adenoma Development
The relevance of the chemokine/chemokine receptor system has broaden to several tissues. Besides their physiologic role as chemotactic cytokines in immune surveillance, it is now clear that chemokines are key players in several pathological processes such as inflammation, infection, and cancer. In particular the altered expression of SDF1/CXCL12 and its receptor CXCR4 strongly affects cancer ce...
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1 Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Milan, Italy, 2 Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy, 3 Department of Pathology, University of Rijeka, Rijeka, Croatia, 4 Division of Hematology and Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA, 5 Department of Neurosurge...
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Pituitary adenomas are classified as typical or atypical, invasive or noninvasive, and aggressive or nonaggressive based on pathological features, radiological findings, and clinical behavior. Only pituitary tumors with cerebrospinal and/or systemic metastasis are considered malignant carcinomas. However, some pituitary adenomas with high Ki-67 indexes exhibit aggressive behaviors, such as rapi...
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Metabolic abnormalities are common in cancers, and targeting metabolism is emerging as a novel therapeutic approach to cancer management. Pituitary adenoma (PA) is a type of benign tumor. Impairment of tumor cells' metabolism in PA seems not to be as apparent as that of other malignant tumor cells; however, aberrant hormone secretion is conspicuous in most PAs. Hormones have direct impacts on s...
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Pituitary adenomas are common benign intracranial neoplasms representing about 10-25% of all intracranial neoplasm. Significant morbidity can occur along with pituitary adenomas due to hormonal dysfunction and mass effects. The pathogenesis of pituitary adenoma is unclear, however, etiologic factors include genetic events, hormonal stimulation, and growth factors [1], all of which promote cell ...
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ژورنال
عنوان ژورنال: The Open Neuroendocrinology Journal
سال: 2011
ISSN: 1876-5289
DOI: 10.2174/1876528901104010064